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optical coherence tomography (oct) microscopy system  (Bioptigen Inc)

 
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    Bioptigen Inc optical coherence tomography (oct) microscopy system
    (A) Schematic <t>of</t> <t>Drosophila</t> genetic screen. Genetic deletion of a segment between cytologic bands 44A and 44B of chromosome 2R, Df(2R)Exel7094, resulted in enlarged cardiac dimensions and diminished cardiac function by <t>OCT.</t> Adjacent genomic deletions Df(2R)Exel6055 and Df(2R)Exel7095 have normal cardiac dimensions, thereby identifying a genomic segment spanning 13 genes as the candidate interval. (B) Representative 1 second OCT recordings from w1118, genomic deletion (Df[2R]Exel7094), P-element single-gene disruption of sandman (PBac{RB}sandman e00867), sandman overexpressed ubiquitously (actin>sandman), sandman overexpressed in cardiac tissue (tinC>sandman) or ubiquitously (actin>sandman), or in the context of the genomic deletion Df(2R)Exel7094 (Df(2R)Exel7094; actin>sandman and Df(2R)Exel7094; tinC>sandman). Scale bar: 125 μm. (C) Average end diastolic dimensions (EDD) and (D) average end systolic dimensions (ESD) reveal marked enlargement and resultant decrease in (E) average fractional shortening (FS) in Df(2R)Exel7094 and PBac{RB}sandman e00867 in comparison with w1118. The ubiquitous and cardiac-specific overexpression of sandman in the context of Df(2R)Exel7094 (Df(2R)Exel7094; actin>sandman and Df(2R)Exel7094; tinC>sandman, respectively) results in rescue of cardiac dimensions in comparison with Df(2R)Exel7094 and PBac{RB}sandman e00867. Statistical comparisons made using 1-way ANOVA with Bonferroni’s test for multiple comparisons. *P < 0.0001 versus w1118; †P < 0.0001 versus Df(2R)Exel7094 and PBac{RB}sandman e00867.
    Optical Coherence Tomography (Oct) Microscopy System, supplied by Bioptigen Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/optical coherence tomography (oct) microscopy system/product/Bioptigen Inc
    Average 90 stars, based on 1 article reviews
    optical coherence tomography (oct) microscopy system - by Bioz Stars, 2026-04
    90/100 stars

    Images

    1) Product Images from "The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction"

    Article Title: The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction

    Journal: The Journal of Clinical Investigation

    doi: 10.1172/JCI95945

    (A) Schematic of Drosophila genetic screen. Genetic deletion of a segment between cytologic bands 44A and 44B of chromosome 2R, Df(2R)Exel7094, resulted in enlarged cardiac dimensions and diminished cardiac function by OCT. Adjacent genomic deletions Df(2R)Exel6055 and Df(2R)Exel7095 have normal cardiac dimensions, thereby identifying a genomic segment spanning 13 genes as the candidate interval. (B) Representative 1 second OCT recordings from w1118, genomic deletion (Df[2R]Exel7094), P-element single-gene disruption of sandman (PBac{RB}sandman e00867), sandman overexpressed ubiquitously (actin>sandman), sandman overexpressed in cardiac tissue (tinC>sandman) or ubiquitously (actin>sandman), or in the context of the genomic deletion Df(2R)Exel7094 (Df(2R)Exel7094; actin>sandman and Df(2R)Exel7094; tinC>sandman). Scale bar: 125 μm. (C) Average end diastolic dimensions (EDD) and (D) average end systolic dimensions (ESD) reveal marked enlargement and resultant decrease in (E) average fractional shortening (FS) in Df(2R)Exel7094 and PBac{RB}sandman e00867 in comparison with w1118. The ubiquitous and cardiac-specific overexpression of sandman in the context of Df(2R)Exel7094 (Df(2R)Exel7094; actin>sandman and Df(2R)Exel7094; tinC>sandman, respectively) results in rescue of cardiac dimensions in comparison with Df(2R)Exel7094 and PBac{RB}sandman e00867. Statistical comparisons made using 1-way ANOVA with Bonferroni’s test for multiple comparisons. *P < 0.0001 versus w1118; †P < 0.0001 versus Df(2R)Exel7094 and PBac{RB}sandman e00867.
    Figure Legend Snippet: (A) Schematic of Drosophila genetic screen. Genetic deletion of a segment between cytologic bands 44A and 44B of chromosome 2R, Df(2R)Exel7094, resulted in enlarged cardiac dimensions and diminished cardiac function by OCT. Adjacent genomic deletions Df(2R)Exel6055 and Df(2R)Exel7095 have normal cardiac dimensions, thereby identifying a genomic segment spanning 13 genes as the candidate interval. (B) Representative 1 second OCT recordings from w1118, genomic deletion (Df[2R]Exel7094), P-element single-gene disruption of sandman (PBac{RB}sandman e00867), sandman overexpressed ubiquitously (actin>sandman), sandman overexpressed in cardiac tissue (tinC>sandman) or ubiquitously (actin>sandman), or in the context of the genomic deletion Df(2R)Exel7094 (Df(2R)Exel7094; actin>sandman and Df(2R)Exel7094; tinC>sandman). Scale bar: 125 μm. (C) Average end diastolic dimensions (EDD) and (D) average end systolic dimensions (ESD) reveal marked enlargement and resultant decrease in (E) average fractional shortening (FS) in Df(2R)Exel7094 and PBac{RB}sandman e00867 in comparison with w1118. The ubiquitous and cardiac-specific overexpression of sandman in the context of Df(2R)Exel7094 (Df(2R)Exel7094; actin>sandman and Df(2R)Exel7094; tinC>sandman, respectively) results in rescue of cardiac dimensions in comparison with Df(2R)Exel7094 and PBac{RB}sandman e00867. Statistical comparisons made using 1-way ANOVA with Bonferroni’s test for multiple comparisons. *P < 0.0001 versus w1118; †P < 0.0001 versus Df(2R)Exel7094 and PBac{RB}sandman e00867.

    Techniques Used: Over Expression



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    optical coherence tomography (oct) microscopy system  (Bioptigen Inc)
    90
    Bioptigen Inc optical coherence tomography (oct) microscopy system
    (A) Schematic <t>of</t> <t>Drosophila</t> genetic screen. Genetic deletion of a segment between cytologic bands 44A and 44B of chromosome 2R, Df(2R)Exel7094, resulted in enlarged cardiac dimensions and diminished cardiac function by <t>OCT.</t> Adjacent genomic deletions Df(2R)Exel6055 and Df(2R)Exel7095 have normal cardiac dimensions, thereby identifying a genomic segment spanning 13 genes as the candidate interval. (B) Representative 1 second OCT recordings from w1118, genomic deletion (Df[2R]Exel7094), P-element single-gene disruption of sandman (PBac{RB}sandman e00867), sandman overexpressed ubiquitously (actin>sandman), sandman overexpressed in cardiac tissue (tinC>sandman) or ubiquitously (actin>sandman), or in the context of the genomic deletion Df(2R)Exel7094 (Df(2R)Exel7094; actin>sandman and Df(2R)Exel7094; tinC>sandman). Scale bar: 125 μm. (C) Average end diastolic dimensions (EDD) and (D) average end systolic dimensions (ESD) reveal marked enlargement and resultant decrease in (E) average fractional shortening (FS) in Df(2R)Exel7094 and PBac{RB}sandman e00867 in comparison with w1118. The ubiquitous and cardiac-specific overexpression of sandman in the context of Df(2R)Exel7094 (Df(2R)Exel7094; actin>sandman and Df(2R)Exel7094; tinC>sandman, respectively) results in rescue of cardiac dimensions in comparison with Df(2R)Exel7094 and PBac{RB}sandman e00867. Statistical comparisons made using 1-way ANOVA with Bonferroni’s test for multiple comparisons. *P < 0.0001 versus w1118; †P < 0.0001 versus Df(2R)Exel7094 and PBac{RB}sandman e00867.
    Optical Coherence Tomography (Oct) Microscopy System, supplied by Bioptigen Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/optical coherence tomography (oct) microscopy system/product/Bioptigen Inc
    Average 90 stars, based on 1 article reviews
    optical coherence tomography (oct) microscopy system - by Bioz Stars, 2026-04
    90/100 stars
    		  Buy from Supplier

    Image Search Results


    (A) Schematic of Drosophila genetic screen. Genetic deletion of a segment between cytologic bands 44A and 44B of chromosome 2R, Df(2R)Exel7094, resulted in enlarged cardiac dimensions and diminished cardiac function by OCT. Adjacent genomic deletions Df(2R)Exel6055 and Df(2R)Exel7095 have normal cardiac dimensions, thereby identifying a genomic segment spanning 13 genes as the candidate interval. (B) Representative 1 second OCT recordings from w1118, genomic deletion (Df[2R]Exel7094), P-element single-gene disruption of sandman (PBac{RB}sandman e00867), sandman overexpressed ubiquitously (actin>sandman), sandman overexpressed in cardiac tissue (tinC>sandman) or ubiquitously (actin>sandman), or in the context of the genomic deletion Df(2R)Exel7094 (Df(2R)Exel7094; actin>sandman and Df(2R)Exel7094; tinC>sandman). Scale bar: 125 μm. (C) Average end diastolic dimensions (EDD) and (D) average end systolic dimensions (ESD) reveal marked enlargement and resultant decrease in (E) average fractional shortening (FS) in Df(2R)Exel7094 and PBac{RB}sandman e00867 in comparison with w1118. The ubiquitous and cardiac-specific overexpression of sandman in the context of Df(2R)Exel7094 (Df(2R)Exel7094; actin>sandman and Df(2R)Exel7094; tinC>sandman, respectively) results in rescue of cardiac dimensions in comparison with Df(2R)Exel7094 and PBac{RB}sandman e00867. Statistical comparisons made using 1-way ANOVA with Bonferroni’s test for multiple comparisons. *P < 0.0001 versus w1118; †P < 0.0001 versus Df(2R)Exel7094 and PBac{RB}sandman e00867.

    Journal: The Journal of Clinical Investigation

    Article Title: The two-pore domain potassium channel TREK-1 mediates cardiac fibrosis and diastolic dysfunction

    doi: 10.1172/JCI95945

    Figure Lengend Snippet: (A) Schematic of Drosophila genetic screen. Genetic deletion of a segment between cytologic bands 44A and 44B of chromosome 2R, Df(2R)Exel7094, resulted in enlarged cardiac dimensions and diminished cardiac function by OCT. Adjacent genomic deletions Df(2R)Exel6055 and Df(2R)Exel7095 have normal cardiac dimensions, thereby identifying a genomic segment spanning 13 genes as the candidate interval. (B) Representative 1 second OCT recordings from w1118, genomic deletion (Df[2R]Exel7094), P-element single-gene disruption of sandman (PBac{RB}sandman e00867), sandman overexpressed ubiquitously (actin>sandman), sandman overexpressed in cardiac tissue (tinC>sandman) or ubiquitously (actin>sandman), or in the context of the genomic deletion Df(2R)Exel7094 (Df(2R)Exel7094; actin>sandman and Df(2R)Exel7094; tinC>sandman). Scale bar: 125 μm. (C) Average end diastolic dimensions (EDD) and (D) average end systolic dimensions (ESD) reveal marked enlargement and resultant decrease in (E) average fractional shortening (FS) in Df(2R)Exel7094 and PBac{RB}sandman e00867 in comparison with w1118. The ubiquitous and cardiac-specific overexpression of sandman in the context of Df(2R)Exel7094 (Df(2R)Exel7094; actin>sandman and Df(2R)Exel7094; tinC>sandman, respectively) results in rescue of cardiac dimensions in comparison with Df(2R)Exel7094 and PBac{RB}sandman e00867. Statistical comparisons made using 1-way ANOVA with Bonferroni’s test for multiple comparisons. *P < 0.0001 versus w1118; †P < 0.0001 versus Df(2R)Exel7094 and PBac{RB}sandman e00867.

    Article Snippet: Cardiac function in adult Drosophila was measured using a custom-built optical coherence tomography (OCT) microscopy system (Bioptigen Inc.), as previously described ( 54 ).

    Techniques: Over Expression